Aptivus Solution

Pronunciation: tye-PRAN-a-vir
Generic Name: Tipranavir
Brand Name: Aptivus

Aptivus Solution is used along with another HIV medicine (ritonavir). Serious and sometimes fatal bleeding in the brain has occurred with this combination. Contact your doctor right away if you develop symptoms of bleeding in the brain. These may include confusion, vision or speech problems, or one-sided weakness.

Serious and sometimes fatal liver problems have also been reported with this combination. Patients who have hepatitis B or C may be at greater risk. Contact your doctor at once if you develop symptoms of liver problems. Such symptoms may include yellowing of the eyes or skin, dark urine, pale stools, stomach pain or tenderness, severe or persistent nausea, or loss of appetite.

Discuss any questions or concerns with your doctor.

Aptivus Solution is used for:

Treating HIV infection. Aptivus Solution should be used with ritonavir.

Aptivus Solution is a protease inhibitor. It works by blocking the growth of an enzyme (HIV protease) that the HIV virus needs to reproduce in the body.

Do NOT use Aptivus Solution if:

• you are allergic to any ingredient in Aptivus Solution


• you have moderate to severe liver disease


• you are taking alfuzosin, certain antiarrhythmics (eg, amiodarone, bepridil, flecainide, propafenone, quinidine), astemizole, certain benzodiazepines (eg, midazolam, triazolam), certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), cisapride, ergot derivatives (eg, ergonovine, ergotamine), other HIV protease inhibitors (eg, saquinavir), pimozide, rifampin, salmeterol, a serotonin 5-HT₁ receptor antagonist (eg, eletriptan, sumatriptan), St. John's wort, or terfenadine


• you are taking sildenafil for pulmonary arterial hypertension (PAH)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Aptivus Solution:

Some medical conditions may interact with Aptivus Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide


• if you have cholesterol or lipid problems, diabetes or a family history of diabetes, liver problems (eg, hepatitis B or C), abnormal liver function tests, kidney problems, or bleeding problems (eg, hemophilia)


• if you take vitamin E or you have had a recent injury or other medical condition that may increase your risk of bleeding or serious bruising


• if you will be having or have recently had surgery


• if you have never taken another medicine for HIV infection

Some MEDICINES MAY INTERACT with Aptivus Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Certain antiarrhythmics (eg, amiodarone, bepridil, flecainide, propafenone, quinidine), astemizole, certain benzodiazepines (eg, midazolam, triazolam), cisapride, ergot derivatives (eg, ergonovine, ergotamine), certain HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), pimozide, salmeterol, serotonin 5-HT₁ receptor antagonists (eg, eletriptan, sumatriptan), or terfenadine because the risk of side effects, including heart or blood vessel problems, muscle problems, or severe breathing problems, may be increased


• Alfuzosin because the risk for severe low blood pressure may be increased


• Rifampin or St. John's wort because they may decrease Aptivus Solution's effectiveness


• Sildenafil (when used for PAH) because the risk of its side effects may be increased by Aptivus Solution


• Other HIV protease inhibitors (eg, saquinavir) because their effectiveness may be decreased by Aptivus Solution


• Anticoagulants (eg, warfarin), antiplatelet medicines (eg, clopidogrel), and many prescription and nonprescription medicines (eg, used for aches and pains, asthma, erectile dysfunction, PAH, diabetes, gout, high blood pressure, high cholesterol, HIV, immune system suppression, infections, inflammation, irregular heartbeat, nasal allergies, seizures), multivitamin products, and herbal or dietary supplements (eg, coenzyme Q10, garlic, ginkgo, ginseng, herbal teas, St. John's wort) may interact with Aptivus Solution, increasing the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aptivus Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Aptivus Solution:

Use Aptivus Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Aptivus Solution. Talk to your pharmacist if you have questions about this information.


• Aptivus Solution is taken at the same time with another medicine called ritonavir. If you are taking Aptivus Solution with ritonavir capsule or solution, it can be taken with or without meals. If you are taking Aptivus Solution with ritonavir tablets, it must be taken with meals.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you are also taking didanosine, do not take it within 2 hours of taking Aptivus Solution. Check with your doctor if you have questions.


• Taking Aptivus Solution at the same time each day will help you remember to take it.


• Take Aptivus Solution on a regular schedule to get the most benefit from it.


• Continue to use Aptivus Solution even if you feel well. Do not miss any doses. Failure to do so may decrease the effectiveness of Aptivus Solution and increase the risk that your HIV infection will no longer be sensitive to Aptivus Solution or to other similar medicines.


• If you miss a dose of Aptivus Solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Aptivus Solution.

Important safety information:

• Aptivus Solution may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Aptivus Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Tell your doctor or dentist that you take Aptivus Solution before you receive any medical or dental care, emergency care, or surgery.


• Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Aptivus Solution. The cause and long-term effects of these changes are not known. Discuss any concerns with your doctor.


• Aptivus Solution may improve immune system function. This may reveal hidden infections in some patients. Tell your doctor right away if you notice symptoms of infection (eg, cough, fever, shortness of breath, sore throat, weakness) after you start Aptivus Solution.


• When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Aptivus Solution, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.


• Aptivus Solution is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.


• Aptivus Solution does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.


• Aptivus Solution may increase triglyceride and lipid levels. The long-term chance of complications from these increased triglyceride and lipid levels, such as heart attack and stroke, are not known at this time.


• Hemophilia patients - Report all bleeding episodes to your doctor.


• Aptivus Solution may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.


• Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Aptivus Solution may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Aptivus Solution. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Hormonal birth control (eg, birth control pills) may not work as well while you are using Aptivus Solution. To prevent pregnancy, use an extra form of birth control (eg, condoms).


• Women who take estrogens for birth control or hormone replacement may have an increased risk of rash from Aptivus Solution. Contact your doctor if you develop a rash.


• Lab tests, including viral load, CD4 count, triglyceride and lipid levels, and liver function, may be performed while you use Aptivus Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Aptivus Solution with caution in the ELDERLY; they may be more sensitive to its effects.


• Caution is advised when using Aptivus Solution in CHILDREN; they may be more sensitive to its effects, especially rash.


• Use Aptivus Solution with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risk of using Aptivus Solution while you are pregnant. It is not known if Aptivus Solution is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Aptivus Solution to the baby.

Possible side effects of Aptivus Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; diarrhea; headache; nausea; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); body fat changes; confusion; dark urine; depression; difficulty urinating; dizziness; excessive hunger, thirst, or urination; fast heartbeat; fever, chills, or sore throat; flu-like symptoms; fruit-like breath odor; itching; joint pain or stiffness; loss of appetite; mental or mood changes; mouth sores or ulcers; muscle pain; numbness or tingling; pale stools; red, blistered, swollen, or peeling skin; severe or persistent nausea; slurred speech or one-sided weakness; stomach pain or tenderness; throat tightness; unusual bruising or bleeding; unusual drowsiness or tiredness; unusual weakness; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

See also: Aptivus side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Aptivus Solution:

Store Aptivus Solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not refrigerate or freeze. Aptivus Solution must be used within 60 days after opening the bottle. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aptivus Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Aptivus Solution, please talk with your doctor, pharmacist, or other health care provider.


• Aptivus Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Aptivus Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Aptivus resources

• Aptivus Side Effects (in more detail)
• Aptivus Use in Pregnancy & Breastfeeding
• Aptivus Drug Interactions
• Aptivus Support Group
• 0 Reviews for Aptivus - Add your own review/rating

Compare Aptivus with other medications

• HIV Infection

Atralin

Generic Name: tretinoin topical (TRET in oin)

Brand Names: Altinac, Atralin, Avita, Renova, Retin A Micro Gel, Retin-A, Tretin-X

What is tretinoin topical?

Tretinoin is a topical (applied to the skin) form of vitamin A that helps the skin renew itself.

The Retin-A and Avita brands of tretinoin are used to treat acne. The Renova brand of tretinoin is used to reduce the appearance of fine wrinkles and mottled skin discoloration, and to make rough facial skin feel smoother.

Tretinoin topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about tretinoin topical?

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Tretinoin topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Avoid getting this medication in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water. Do not use tretinoin topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using tretinoin topical. Use this medication for as many days as it has been prescribed for you even if you think it is not working. It may take weeks or months of use before you notice improvement in your skin. If you are using tretinoin topical to treat acne, your condition may get slightly worse for a short time when you first start using the medication. Call your doctor if skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks.

What should I discuss with my healthcare provider before using tretinoin topical?

FDA pregnancy category C. It is not known whether tretinoin topical is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Tretinoin topical can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use tretinoin topical?

Use tretinoin topical exactly as your doctor has prescribed it for you. Using more medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects. Do not use this medication for longer than your doctor has prescribed.

Wash your hands before and after applying tretinoin topical. Before applying, clean and dry the skin area to be treated.

Applying tretinoin topical to wet skin may cause skin irritation. If you use Renova, wait at least 20 minutes after washing your face before applying a thin layer of the medication.

Do not wash the treated area for at least 1 hour after applying tretinoin topical. Avoid the use of other skin products on the treated area for at least 1 hour following application of tretinoin topical.

Applying an excessive amount of tretinoin gel may result in "pilling" of the medication. If this occurs, use a thinner layer of gel with the next application.

Tretinoin topical should be used as part of a complete skin care program that includes avoiding sunlight and using an effective sunscreen and protective clothing.

Use this medication for as many days as it has been prescribed for you even if you think it is not working. It may take weeks or months of use before you notice improvement in your skin. If you are using tretinoin topical to treat acne, your condition may get slightly worse for a short time when you first start using the medication. Call your doctor if skin irritation becomes severe or if your acne does not improve within 8 to 12 weeks. Store tretinoin topical at room temperature away from moisture and heat. The gel formulations of Retin-A are flammable, keep them away from open flame.

What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not apply extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Tretinoin topical is not expected to cause overdose symptoms.

What should I avoid while using tretinoin topical?

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Tretinoin topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Avoid getting this medication in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water. Do not use tretinoin topical on skin that is sunburned, windburned, dry, chapped, or irritated. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using tretinoin topical.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medication skin products unless your doctor has told you to.

Your skin may be more sensitive to weather extremes such as cold and wind while using this medicine.

Tretinoin topical side effects

Stop using this medication and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include burning, warmth, stinging, tingling, itching, redness, swelling, dryness, peeling, irritation, or discolored skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect tretinoin topical?

Do not use skin products that contain benzoyl peroxide, sulfur, resorcinol, or salicylic acid unless otherwise directed by your doctor. These products can cause severe skin irritation if used with tretinoin topical.

The following drugs can interact with tretinoin topical, which can make your skin more sensitive to natural and artificial sunlight. Before using this medication, tell your doctor if you are using any of these:

• 
  

  a diuretic (water pill);

  
  


• 
  

  tetracycline (Sumycin, Panmycin, Robitet), minocycline (Minocin), doxycycline (Doryx, Vibramycin), demeclocycline (Declomycin), and others;

  
  


• 
  

  an antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), and others;

  
  


• 
  

  a sulfa drug such as Bactrim, Septra, Cotrim, and others; or

  
  


• 
  

  chlorpromazine (Thorazine), prochlorperazine (Compazine), fluphenazine (Permitil, Prolixin), promethazine (Phenergan, Promethegan), perphenazine (Trilafon), and others.

  
  

This list is not complete and there may be other drugs that can affect tretinoin topical. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Atralin resources

• Atralin Side Effects (in more detail)
• Atralin Use in Pregnancy & Breastfeeding
• Atralin Drug Interactions
• Atralin Support Group
• 24 Reviews for Atralin - Add your own review/rating

• Atralin Topical Advanced Consumer (Micromedex) - Includes Dosage Information


• Atralin Consumer Overview


• Avita Prescribing Information (FDA)


• Avita Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Refissa Prescribing Information (FDA)


• Renova Emollient Cream MedFacts Consumer Leaflet (Wolters Kluwer)


• Renova Consumer Overview


• Retin-A Prescribing Information (FDA)


• Tretin-X Cream MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Atralin with other medications

• Acne
• Photoaging of the Skin

Where can I get more information?

• Your pharmacist can provide more information about tretinoin topical.

See also: Atralin side effects (in more detail)

Air

Dosage Form: inhalation gas
Air Label

DO NOT REMOVE THIS LABEL

Air COMPRESSED USP

UN 1002    

CAS: 132259-10-0

NON-FLAMMABLE GAS 2

CAUTION - HIGH PRESSURE GAS. MAY ACCELERATE COMBUSTION

CAUTION: Keep oil and grease away. Use equipment rated for cylinder pressure. Cylinder temperature should not exceed 125f (52c). Close valve tightly and replace cylinder cap when not in use and when empty. USE IN ACCORDANCE WITH MED-TECH MATERIAL SAFETY DATA SHEET.

WARNING: Administration of compressed Air to humans for breathing maintenance should be by adequately trained personnel experienced in the use and administration of compressed Air.

1994

MEDTECH Since 1961

Medical-Technical Gases, Inc.

20 Hall Street, Medford, MA 02155

617-395-1946  FAX 617- 395-9098

Air  Air  gas

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 10736-016 Route of Administration RESPIRATORY (INHALATION) DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Air (Air) Air 1000 mL  in 1 L

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 10736-016-01 346 L In 1 CYLINDER None 2 10736-016-02 720 L In 1 CYLINDER None 3 10736-016-03 2246 L In 1 CYLINDER None 4 10736-016-04 3327 L In 1 CYLINDER None 5 10736-016-05 6507 L In 1 CYLINDER None 6 10736-016-06 8724 L In 1 CYLINDER None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved medical gas		01/01/1963

Labeler - Medical-Technical Gases, Inc. (019481373)

Establishment
Name	Address	ID/FEI	Operations
Medical-Technical Gases, Inc.		019481373	manufacture

Revised: 02/2012Medical-Technical Gases, Inc.

AK-Dilate

Generic Name: phenylephrine ophthalmic (fen ill EFF rin)

Brand Names: AK-Dilate, AK-Nefrin, Isopto Frin, Mydfrin, Neo-Synephrine Ophthalmic, Neofrin

What is AK-Dilate (phenylephrine ophthalmic)?

Phenylephrine ophthalmic causes constriction of blood vessels in the eyes. It also enlarges the pupils, reduces the production of fluid in the eyes, and increases the amount of fluid that drains from the eyes.

Phenylephrine ophthalmic available over-the-counter is used to relieve redness, burning, irritation, and dryness of the eye caused by wind, sun, and other minor irritants. Prescription-strength phenylephrine ophthalmic is used to constrict blood vessels in the eye and to dilate (make bigger) the pupil for conditions such as glaucoma, before surgery, and before eye examinations.

Phenylephrine ophthalmic may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about AK-Dilate (phenylephrine ophthalmic)?

Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.

If you wear contact lenses, remove them before applying phenylephrine ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Phenylephrine ophthalmic may contains preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

Do not use phenylephrine ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen. Use caution when driving, operating machinery, or performing other hazardous activities. Phenylephrine ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities.

What should I discuss with my healthcare provider before using AK-Dilate (phenylephrine ophthalmic)?

Do not use phenylephrine ophthalmic if you have glaucoma, except under the supervision of your doctor.

Do not use phenylephrine ophthalmic after eye surgery, if you have an eye infection, if you have an eye injury, or if you have a problem with the normal tearing of your eyes without the approval and direction of your doctor. Using phenylephrine ophthalmic under these circumstances could lead to absorption of the drug by the body, and side effects could affect the heart.

Before using this medication, tell your doctor if you

• 
  

  have any type of heart condition, including high blood pressure;

  
  


• 
  

  take any medicines to treat a heart condition;

  
  


• 
  

  have asthma;

  
  


• 
  

  have diabetes; or

  
  


• 
  

  have thyroid problems.

  
  

You may not be able to use phenylephrine ophthalmic, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Phenylephrine ophthalmic is in the FDA pregnancy category C. This means that it is not known whether phenylephrine ophthalmic will be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether phenylephrine ophthalmic passes into breast milk. Do not use phenylephrine ophthalmic without first talking to your doctor if you are breast-feeding a baby.

How should I use AK-Dilate (phenylephrine ophthalmic)?

Use phenylephrine eyedrops exactly as directed by your doctor, or follow the directions that accompany the package. If you do not understand these instructions, ask your doctor, pharmacist, or nurse to explain them to you.

Wash your hands before and after using the eyedrops.

If you wear contact lenses, remove them before applying phenylephrine ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Phenylephrine ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

To apply the eyedrops:

• 
  

  Tilt the head back slightly and pull down on the lower eyelid. Position the dropper above the eye. Look up and away from the dropper. Squeeze out a drop and close the eye. Apply gentle pressure to the inside corner of the eye (near the nose) for about 1 minute to prevent the liquid from draining down the tear duct. Repeat the process in the other eye if needed.

  
  

Do not use phenylephrine ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen. Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye. Do not use any eyedrop that is discolored or has particles in it. Store phenylephrine ophthalmic at room temperature away from moisture and heat. Keep the bottle properly capped.

What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not use a double dose of this medication.

What happens if I overdose?

An overdose of this medication is unlikely to be harmful. If you do suspect an overdose, or if the drops have been ingested (taken by mouth), contact an emergency room or poison control center for advice.

What should I avoid while using AK-Dilate (phenylephrine ophthalmic)?

Use caution when driving, operating machinery, or performing other hazardous activities. Phenylephrine ophthalmic may cause blurred vision. If you experience blurred vision, avoid these activities. Do not touch the dropper to any surface, including the eyes or hands. The dropper is sterile. If it becomes contaminated, it could cause an infection in the eye.

If you wear contact lenses, remove them before applying phenylephrine ophthalmic. Ask your doctor if contact lenses can be reinserted after application of the medication. Phenylephrine ophthalmic may contain a preservative (benzalkonium chloride), which may cause discoloration of contact lenses.

Do not use phenylephrine ophthalmic more often or continuously for longer than 48 to 72 hours without consulting a doctor. Chronic use of this medication may damage the blood vessels (veins and arteries) in the eyes. Consult a doctor if your symptoms do not improve or appear to worsen.

AK-Dilate (phenylephrine ophthalmic) side effects

If you experience any of the following serious side effects, stop using phenylephrine ophthalmic and seek emergency medical attention or contact your doctor immediately:

• 
  

  an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; or hives);

  
  


• 
  

  an irregular or fast heart rate; or

  
  


• 
  

  high blood pressure (severe headache, blurred vision, or flushed skin).

  
  

Other, less serious side effects may be more likely to occur. Continue to use phenylephrine ophthalmic and talk to your doctor if you experience

• 
  

  burning, stinging, pain, or increased redness of the eye;

  
  


• 
  

  tearing or blurred vision;

  
  


• 
  

  headache;

  
  


• 
  

  tremor;

  
  


• 
  

  nausea;

  
  


• 
  

  sweating;

  
  


• 
  

  nervousness;

  
  


• 
  

  dizziness; or

  
  


• 
  

  drowsiness.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect AK-Dilate (phenylephrine ophthalmic)?

Do not use other eye medications during treatment with phenylephrine ophthalmic except under the direction of your doctor.

Although drug interactions between phenylephrine ophthalmic and drugs taken by mouth are not expected, they can occur. Before using this medication, tell your doctor if you are taking any of the following medicines:

• 
  

  a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil); or

  
  


• 
  

  a beta-blocker such as propranolol (Inderal), metoprolol (Lopressor, Toprol XL), or labetalol (Normodyne, Trandate).

  
  

You may not be able to use phenylephrine ophthalmic, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with phenylephrine ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

More AK-Dilate resources

• AK-Dilate Side Effects (in more detail)
• AK-Dilate Use in Pregnancy & Breastfeeding
• AK-Dilate Drug Interactions
• AK-Dilate Support Group
• 0 Reviews for AK-Dilate - Add your own review/rating

• AK-Dilate Ophthalmic Advanced Consumer (Micromedex) - Includes Dosage Information


• AK-Dilate Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Ak-Dilate Ophthalmic Advanced Consumer (Micromedex) - Includes Dosage Information


• Altafrin Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Compare AK-Dilate with other medications

• Eye Dryness/Redness
• Eye Redness/Itching
• Pupillary Dilation

Where can I get more information?

• Your pharmacist has additional information about phenylephrine ophthalmic written for health professionals that you may read.

See also: AK-Dilate side effects (in more detail)

Airet Solution

Pronunciation: al-BUE-ter-ol
Generic Name: Albuterol
Brand Name: Examples include Airet and Proventil

Airet Solution is used for:

Treating breathing problems in patients who have asthma or certain other airway diseases. It may also be used for other conditions as determined by your doctor.

Airet Solution is a sympathomimetic (beta agonist) bronchodilator. It works by relaxing the smooth muscle in the airway, which allows air to flow in and out of the lungs more easily.

Do NOT use Airet Solution if:

• you are allergic to any ingredient in Airet Solution


• you are using another short-acting sympathomimetic bronchodilator (eg, metaproterenol) or epinephrine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Airet Solution:

Some medical conditions may interact with Airet Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of heart problems, (eg, fast or irregular heartbeat, heart failure), blood vessel problems, high blood pressure, or low blood potassium levels


• if you have a history of seizures, diabetes, an overactive thyroid, kidney problems, or an adrenal gland tumor (pheochromocytoma)


• if you have ever had an unusual reaction to another sympathomimetic medicine (eg, pseudoephedrine)


• if you are taking a monoamine oxidase inhibitors (MAOI) (eg, phenelzine), or tricyclic antidepressant (eg, amitriptyline), or if you have taken either of these medicines within the last 14 days

Some MEDICINES MAY INTERACT with Airet Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood potassium levels may be increased


• Catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), epinephrine, MAOIs (eg, phenelzine), short-acting sympathomimetic bronchodilators (eg, metaproterenol), stimulants (eg, amphetamine), sympathomimetics (eg, pseudoephedrine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Airet Solution's side effects


• Beta-blockers (eg, propranolol) because they may decrease Airet Solution's effectiveness


• Digoxin because its effectiveness may be decreased by Airet Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Airet Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Airet Solution:

Use Airet Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Airet Solution. Talk to your pharmacist if you have questions about this information.


• Airet Solution is for inhalation only. Do not get it in the eyes. If you get Airet Solution in the eyes, rinse immediately with cool tap water.


• Remove a vial from the foil pouch. Place the remaining vials back into the pouch for storage.


• Do not use Airet Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• To use Airet Solution, twist open the top of the vial and pour the entire contents into the nebulizer reservoir.


• Connect the nebulizer reservoir to the mouthpiece or face mask. Connect the nebulizer to the compressor.


• Sit in a comfortable, upright position. Place the mouthpiece in your mouth (or put on the face mask) and turn on the nebulizer.


• Breathe as calmly, deeply, and evenly as possible until no more mist is formed in the nebulizer chamber (about 5 to 15 minutes).


• Clean the nebulizer according to the instructions. Failure to properly clean the nebulizer could lead to bacteria entering the medicine. This may lead to an infection. To avoid bacteria entering the medicine, use the entire contents right after opening the vial for the first time.


• Do not stop using Airet Solution without checking with your doctor.


• Do not mix Airet Solution with other medicines in the nebulizer unless directed otherwise by your doctor.


• If you miss a dose of Airet Solution and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Airet Solution.

Important safety information:

• Airet Solution may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Airet Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Airet Solution may sometimes cause severe breathing problems right after you use a dose. If this happens, seek medical care at once.


• If your usual dose does not work well, your symptoms become worse, or you need to use it more often than normal, contact your doctor at once. This may be a sign of seriously worsening asthma. Your doctor may need to change your dose or medicine.


• Airet Solution should work for up to 6 hours. Do NOT use more than the recommended dose or use more often than prescribed without checking with your doctor. The risk of severe heart problems and sometimes death may be increased with overuse of Airet Solution.


• Airet Solution may cause dry mouth or an unpleasant taste in your mouth. Rinsing your mouth with water after each dose may help relieve these effects.


• Tell your doctor or dentist that you take Airet Solution before you receive any medical or dental care, emergency care, or surgery.


• Check with your doctor before using any other inhaled medicines while you are using Airet Solution.


• Diabetes patients - Airet Solution may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• When your medicine supply begins to run low, call your doctor or pharmacy as soon as possible for a refill.


• Use Airet Solution with caution in the ELDERLY; they may be more sensitive to its effects.


• Airet Solution should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.


• Caution is advised when using Airet Solution in CHILDREN; they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Airet Solution while you are pregnant. It is not known if Airet Solution is found in breast milk. If you are or will be breast-feeding while you use Airet Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Airet Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; dizziness; headache; nausea; nervousness; sinus inflammation; sore or dry throat; tremor; trouble sleeping; unusual taste in mouth; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; ear pain; fast or irregular heartbeat; new or worsened trouble breathing; pounding in the chest; severe headache or dizziness; unusual hoarseness; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Airet side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fast or irregular heartbeat; seizures; severe headache or dizziness; severe or persistent nervousness or trouble sleeping; tremor.

Proper storage of Airet Solution:

Store Airet Solution between 36 and 77 degrees F (2 and 25 degrees C). Store in the protective foil pouch at all times. Store away from heat, moisture, and light. Do not store in the bathroom. Do not use after the expiration date on the container or box. Keep Airet Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Airet Solution, please talk with your doctor, pharmacist, or other health care provider.


• Airet Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Airet Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Airet resources

• Airet Side Effects (in more detail)
• Airet Use in Pregnancy & Breastfeeding
• Airet Drug Interactions
• Airet Support Group
• 0 Reviews for Airet - Add your own review/rating

Compare Airet with other medications

• Asthma, acute
• Asthma, Maintenance
• Bronchospasm Prophylaxis
• COPD, Acute
• COPD, Maintenance

Agrylin

Pronunciation: an-AG-re-lide
Generic Name: Anagrelide
Brand Name: Agrylin

Agrylin is used for:

Treating patients with high blood platelet levels (thrombocythemia) due to bone marrow problems. It may also be used for other conditions as determined by your doctor.

Agrylin is a platelet-reducing agent. It works by decreasing the body's production of platelets, which helps to prevent blood clots.

Do NOT use Agrylin if:

• you are allergic to any ingredient in Agrylin


• you have severe liver disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Agrylin:

Some medical conditions may interact with Agrylin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have heart, lung, liver, or kidney problems

Some MEDICINES MAY INTERACT with Agrylin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sucralfate because it may decrease Agrylin's effectiveness


• Amrinone, aspirin, cilostazol, enoximone, milrinone, or olprinone because their actions and the risk of their side effects may be increased by Agrylin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Agrylin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Agrylin:

Use Agrylin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Agrylin by mouth with or without food.


• Take Agrylin on a regular schedule to get the most benefit from it. It may take several weeks (4 to 12 weeks) before you get the full effect from Agrylin.


• If you miss a dose of Agrylin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Agrylin.

Important safety information:

• Agrylin may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Agrylin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Agrylin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Agrylin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Agrylin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Agrylin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Severe lung problems (eg, interstitial pneumonitis) have been reported in some patients who take Agrylin. This may develop within 1 week to several years after starting the medicine. Tell your doctor right away if you develop new or worsening shortness of breath or trouble breathing. Talk with your doctor for more information.


• Tell your doctor or dentist that you are using Agrylin before you have any medical or dental care, emergency care, or surgery.


• Lab tests, including liver function, kidney function, blood pressure, and complete blood cell counts, may be performed while you use Agrylin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• If you may become pregnant, you must use an effective form of birth control while you take Agrylin. If you have questions about effective birth control, talk with your doctor.


• PREGNANCY and BREAST-FEEDING: Agrylin may cause harm to the fetus. Avoid becoming pregnant while taking Agrylin. If you think you may be pregnant, contact your doctor right away. It is not known if Agrylin is found in breast milk. Do not breast feed while taking Agrylin.

Possible side effects of Agrylin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; cough; diarrhea; dizziness; drowsiness; gas; general body discomfort; headache; joint or muscle weakness; loss of appetite; nausea; stomach pain; tiredness; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine, stools, or vomit; changes in vision; chest pain, especially if sharp or crushing; decreased urination; depression; easy bruising or bleeding; fainting; fast or irregular heartbeat; flu-like symptoms (eg, sore throat, fever, or chills); memory loss; mental or mood changes; numbness or tingling of your skin or of an arm or leg; one-sided weakness; pounding in the chest; seizures; severe stomach pain; sudden leg pain; sudden, severe headache, vomiting, dizziness, or fainting; shortness of breath; swelling of the hands, legs, or feet; trouble urinating; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Agrylin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fast heartbeat; unusual bleeding and bruising; vomiting.

Proper storage of Agrylin:

Store Agrylin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Agrylin out of the reach of children and away from pets.

General information:

• If you have any questions about Agrylin, please talk with your doctor, pharmacist, or other health care provider.


• Agrylin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Agrylin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Agrylin resources

• Agrylin Side Effects (in more detail)
• Agrylin Use in Pregnancy & Breastfeeding
• Drug Images
• Agrylin Drug Interactions
• Agrylin Support Group
• 0 Reviews for Agrylin - Add your own review/rating

• Agrylin Prescribing Information (FDA)


• Agrylin Advanced Consumer (Micromedex) - Includes Dosage Information


• Agrylin Concise Consumer Information (Cerner Multum)


• Agrylin Monograph (AHFS DI)


• Anagrelide Prescribing Information (FDA)


• Anagrelide Professional Patient Advice (Wolters Kluwer)

Compare Agrylin with other medications

• Chronic Myelogenous Leukemia
• Thrombocythemia

Agri-Cillin

Dosage Form: FOR ANIMAL USE ONLY
Agri-Cillin®

Injectable Antibiotic

NADA 065-010, Approved by FDA

For use in Cattle, Sheep, Swine and Horses.

PENICILLIN G PROCAINE

INJECTABLE SUSPENSION U.S.P.

READ ENTIRE BROCHURE CAREFULLY BEFORE USING THIS PRODUCT

Description:

Agri-Cillin is a suspension of penicillin G procaine in 100,250, and 500 mL multiple dose vials. Each mL is designed to provide 300,000 units of penicillin G as procaine in a stable suspension. Penicillin G procaine is an antibacterial agent which has activity against a variety of pathogenic organisms, mainly in the Gram-positive category.

Indications:

Agri-Cillin is indicated for treatment of bacterial pneumonia (shipping fever) caused by Pasteurella multocida in cattle and sheep, erysipelas caused by Erysipelothrix rhusiopathiae in swine, and strangles caused by Streptococcus equi in horses.

Directions for Use:

A thoroughly cleaned, sterile needle and syringe should be used for each injection (needles and syringes may be sterilized in boiling water for 15 minutes). Before withdrawing the solution from the bottle, disinfect the rubber cap top with 70% alcohol. The injection site should be similarly disinfected with alcohol. Needles of 16 to 18 gauge and 1 to 1.5 inches long are adequate for intramuscular injections.

In livestock intramuscular injections should be made by directing the needle of suitable gauge and length into the fleshy part of a thick muscle, such as rump, hip, or thigh region; avoid blood vessels and major nerves. Before injecting the solution, pull back gently on the plunger. If blood appears in the syringe, a blood vessel has been entered; withdraw the needle and select a different site.

Dosage:

Agri-Cillin is administered by the intramuscular route. The product is ready for injection after warming the vial to room temperature and shaking to ensure a uniform suspension.

The daily dose of penicillin is 3,000 units per pound of body weight (1 mL per 100 lbs body weight). Continue daily treatment until recovery is apparent and for at least one day after symptoms disappear, usually in two to three days.

Treatment should not exceed four consecutive days.

No more than 10 mL should be injected at any one site. Rotate injection sites for each succeeding treatment.

Care of Sick Animals:

The use of antibiotics in the management of diseases is based on an accurate diagnosis and an adequate course of treatment. When properly used in the treatment of diseases caused by penicillin-susceptible organisms, most animals treated with Agri-Cillin show a noticeable improvement within 24 to 48 hours. If improvement does not occur within this period of time, the diagnosis and course of treatment should be re-evaluated. It is recommended that the diagnosis and treatment of animal diseases be carried out by a veterinarian.

Since many diseases look alike but require different types of treatment, the use of professional veterinary and laboratory services can reduce treatment time, costs and needless losses. Good housing, sanitation and nutrition are important in the maintenance of healthy animals and are essential in the treatment of disease.

Residue Warnings:

Exceeding the daily dosage of 3,000 units per pound of body weight, administering for more than four consecutive days, or exceeding the maximum injection site volume per injection site may result in antibiotic residues beyond the withdrawal time.

Milk taken from treated dairy animals within 48 hours after the last treatment must not be used for food. Discontinue use of this drug for the following time period before treated animals are slaughtered for food:

Cattle-14 days, Sheep-9 days, Swine - 7 days.

A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Warning:

Do not use in horses intended for human consumption. Not for use in humans. Keep out of reach of children.

Precautions:

Intramuscular injection in cattle, sheep, and swine may result in a local tissue reaction which persists beyond the withdrawal period of 14 days (cattle), 9 days (sheep), or 7 days (swine). This may result in trim loss of edible tissue at slaughter.

Allergic or anaphylactic reactions, sometimes fatal, have been known to occur in animals hypersensitive to penicillin and procaine. Such reactions can occur unpredictably with varying intensity. Animals administered penicillin G procaine should be kept under close observation for at least one half hour. Should allergic or anaphylactic reactions occur, discontinue use of the product and call a veterinarian. If respiratory distress is severe, immediate injection of epinephrine or antihistamine following manufacturer's recommendations may be necessary.

As with all antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. A lack of response by the treated animal, or the development of new signs or symptoms suggest that an overgrowth of nonsusceptible organisms has occurred. In such instances, consult your veterinarian.

It is advisable to avoid giving penicillin in conjunction with bacteriostatic drugs such as tetracyclines.

Storage Conditions:

Agri-Cillin should be stored between 2 to 8°C (36 to 46°F).

Restricted Drug - California.

Use Only as Directed.

Made in the UK.

Norbrook Laboratories Limited

Newry, Northern Ireland

Distributed by:

Agri Laboratories, Ltd.

St. Joseph, MO 64503

www.AgriLabs.com

006107I01

® Registered Trademark of Agri Laboratories, Ltd.

AgriLabs®

Making A Healthy Difference®

Principal Display Panel – 500 mL Vial Label

Agri-Cillin®

NDC 57561 065 05

STERILE PENICILLIN G PROCAINE

INJECTABLE SUSPENSION U.S.P.

INJECTABLE ANTIBIOTIC

IN AQUEOUS SUSPENSION

300,000 UNITS PER mL

ANTIBIOTIC

FOR INTRAMUSCULAR INJECTION ONLY

NADA 065-010, APPROVED BY FDA

Net Contents: 500 mL

AgriLabs®

Making A Healthy Difference®

AGRICILLIN  penicillin g procaine  injection, suspension

Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 57561-065 Route of Administration INTRAMUSCULAR DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength penicillin G procaine (penicillin G) penicillin G procaine 300000 [USP'U]  in 1 mL

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 57561-065-02 100 mL In 1 VIAL, GLASS None 2 57561-065-04 250 mL In 1 VIAL, GLASS None 3 57561-065-05 500 mL In 1 VIAL, GLASS None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NADA	NADA065010	01/01/2004

Labeler - Agri Laboratories Limited (155594450)

Registrant - Norbrook Laboratories Limited (214580029)

Establishment
Name	Address	ID/FEI	Operations
Station Works		214580029	MANUFACTURE, ANALYSIS

Establishment
Name	Address	ID/FEI	Operations
Carnbane Industrial Estate		211218325	MANUFACTURE

Revised: 02/2011Agri Laboratories Limited